On the Growth Mechanics of the Hynobiid Limb Bud

V. G. Borkhvardt


Limb bud in Ranodon and Salamandrella growths along the preaxial-postaxial axis much more intensive than along the medial-lateral one. This distinction correlates with the structural differences of the basement membrane, which is very thin or even absent at the pre- and postaxial edges. The outgrowth promoting effect of weakening of the basement membrane can be intensified by additional transformations of the ectoderm. After destruction of the basement membrane at pre- and postaxial edges, mesodermal extracellular matrix penetrates the epithelium and forms notches within it. These notches («exterior spaces») broaden under the pressure of mesodermal matrix and become the real parts of the principal limb bud core.


Ranodon; Salamandrella; limb buds; growth mechanics

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DOI: https://doi.org/10.30906/1026-2296-2001-8-1-54-58


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